Most eye surgeries, including LASIK, carry risk of cataracts. Anecdotal reports of cataracts shortly after LASIK, even in relatively young patients, suggest a cause and effect relationship. Moreover, steriod drops routinely prescribed after LASIK may hasten the onset of cataracts.
Patients with signs of cataracts before LASIK should not have LASIK because vision may be corrected with the intraocular lens used for cataract surgery. Ironically, after LASIK the altered corneal surface causes inaccurate measurement of the intraocular lens power for cataract surgery. This means that patients who have LASIK surgery and later develop cataracts may be right back in glasses after cataract surgery -- or worse, subjected to the inherent risks of multiple surgeries.
What should you do if you have had LASIK? Print this form (K-card) and have it completed by your LASIK surgeon. Do not delay, as medical records may be destroyed after five years in some states. Read more about the importance of the K-card below.
If you developed early cataracts after LASIK, you should file a MedWatch report online with the FDA. Alternatively, you may call FDA at 1-800-FDA-1088 to report by telephone, or download a copy of the paper form and either fax it to 1-800-FDA-0178 or mail it using the postage-paid addressed form. Read a sample of LASIK MedWatch reports currently on file with the FDA.
Importance of receiving a K-card after LASIK
A letter with 126 signatures of concerned citizens was sent to the FDA on 11/2/2009 asking the agency to issue a LASIK Public Health Advisory. From the letter: "As stated, LASIK surgery results in miscalculation of lens implant power for future cataract surgery. In 2008, the FDA announced on its web site that it had "worked with the American Academy of Ophthalmology to develop a card that physicians can fill out with the patient's eye measurements before their LASIK surgery." Unfortunately, LASIK surgeons do not routinely provide patients with a K-card. Retention of medical records by healthcare providers is required by state laws; however, in many states medical records may be destroyed after five years. The majority of LASIK patients in the United States are not aware of the need to obtain their pre-LASIK eye measurement records. Therefore, it is incumbent upon the FDA to include this information in a public health advisory concerning LASIK eye surgery." The FDA never acknowledged receipt of the letter, and has continued to ignore this important public health issue.
Although LASIK surgeons routinely fail to provide patients with a K-card, LASIK surgeon professional organizations stress its importance. On its website, the International Society of Refractive Surgery (ISRS) tells patients, "It's crucial to keep a record of pre- and post-operation information that may be needed for future eye surgery, such as cataract surgery. The K Card is an essential part of the refractive surgery patient's health files." Link to source To LASIK surgeons, the organization says, "The 'K-card' which captures a patient's preoperative keratometry readings and refraction should be given to LASIK patients. It is often difficult to track down this critical data years later, when the patient is need of cataract surgery or additional eye care. There are a lot of complicated IOL power calculation formulas, but they all have one factor in common -- they work best when you have the patient's preop keratometry readings and refraction." Link to source
Read what one optometrist wrote to fellow optometrists about this issue: "It is important to inform any corneal refractive patient of the significance of this pre- and postoperative information. The second step is to make the information available to them... The use of this card demonstrates to your patients that you care about their future vision needs... Most importantly, though, making this information available will help your patients in the future." Link to source
There is really only one reason why LASIK surgeons fail to provide patients with a K-card, and that is because alerting patients to the consequences of having LASIK is bad for business. LASIK surgeons don't seem to care what happens to their patients in the future.
Cataracts after LASIK reported to the FDA - 4/1/2014
I had LASIK surgery on both eyes in [redacted by FDA] 2012. By [redacted by FDA] 2013, the sight in my left eye began to greatly deteriorate and my LASIK surgeon performed an enhancement that did not work. I began experiencing cloudiness and pain in my left eye. When I went back he told me that I had an aggressively growing cataract in my left eye. I am only [redacted by FDA] and I am scheduled to have the cataract in my left eye removed next week, I have also suffered from extreme dry eye since the LASIK surgery. I am extremely disappointed that this was not mentioned as a possible complication from the LASIK surgery. Had I known I could possibly develop cataracts, I would not have elected to have the LASIK procedure.
Laura A. - 3/3/2014
I had Lasik surgery the summer of 2009 at age 45. I was considered a good candidate for the surgery. I had very good vision (20/15) for almost 2 years, but then started noticing changes. My regular eye doctor thought that I was simply suffering from dry eye. After about 8 months of treatment, the doctor could see cataracts forming. I just had cataract surgery on my left eye Feb 26, 2014 at age 50, only 2-1/2 years after noticing the first vision degradation. The cataract was rated 3+. This cataract caused blurring and multiple images, rather than cloudiness or discoloration. I also have a cataract forming in my right eye, though it isn't progressing as aggressively as the left eye did. I do not have any health issues such as diabetes, I never took steroids except for the eye drops after Lasik surgery, and I have never had any type of eye injury which would cause early cataracts. I believe that the Lasik surgery or follow-up eye drops caused me to develop early, aggressive cataracts.
Patient reports cataracts after LASIK to FDA, problems calculating IOL power due to LASIK - 1/21/2014
I underwent LASIK surgery around 1999. A few years later, I was diagnosed with a cataract in my left eye. I put off cataract surgery as long as possible; and now at age [redacted by FDA], I have cataracts in both eyes. My vision is so affected that I have fallen several times because I could not see objects on the floor in nighttime lamp light. To make matters worse, my cataract surgeon explained that the cataract surgery will be difficult because the medical equipment used to determine the refraction needed in the replacement lens uses a ratio of two surfaces in a non-LASIK eye. Thus, the surgeon will have to use other formulas and manually determine what strength the implanted lens should be basically, he will have to guess. If LASIK surgery is going to be performed w/o telling patients that early cataracts are more likely to develop, at least tell the patients to keep a copy of their LASIK surgical records so that subsequent cataracts surgery can be performed w/o "estimating" or guessing what replacement lens is needed to restore sight.
M. Adams - 12/18/2012
I'm 38 yrs old and had Lasik performed on my eyes in March of this year (2012). The doctor that performed the procedure told me that I had a cataract in my right eye and that I would need to have it removed in probably 10-15 years. They did the Lasik and within 3 months the cataract had grown so quickly that I could not drive at night anymore. I had to have cataract surgery in September. As I was healing from that, my vision started to quickly fade in the left eye and I was diagnosed with a cataract in that eye as well. I had to have it removed this month. Now after spending close to $7000, my vision is worse than before I first went to this facility.
Young patient reports cataracts after LASIK to the FDA 9/14/2012
Lasik surgery done to correct a nearsighted vision problem in 2003, with a touch up done in 2004. Within a couple of years diagnosed with cataracts in both eyes. Just completed cataract removal in one eye with mixed results. Still need removal of cataract in right eye. Suspect original LASIK surgery performed at [redacted by FDA] as cause and effect of cataracts at such a young age. Better warnings and public awareness are needed to fully inform pts. Cataracts were never listed as an increased possibility at the initial surgery by [redacted by FDA]. I suspect I will need yet another eye surgery to again correct my vision, as less than desired results have happened with the removal of the left cataract.
Cataracts after LASIK reported to FDA 9/9/2012
I had LASIK surgery approximately 12 years ago and now must undergo cataract surgery. I am all of [redacted by FDA], which is relatively young for this type of surgery. My ophthalmologist attributes this to the LASIK, though he cannot definitively confirm it. Lasik surgery approximately year 2000.
Adverse Event Reported to the FDA 7/12/2012
In 1999, at the age of [redacted], I had LASIK eye surgery. One year later, I was back in contacts and had developed cataracts in both eyes. In 2000, although the eye doctor could identify my cataracts in both eyes, it did not affect my vision. That changed in 2012 and now at the age of [redacted], I need to have cataract surgery. I do not have a family history of cataracts. Both of my parents over the age of [redacted] have not had any signs of cataracts. Lasik was performed by [redacted].
Linda S. - 7/24/2012
I had LASIK SURGERY on both eyes Dec. of 2006. I now have cataracts in both eyes and have been informed that the surgery I had complicates the correction of cataracts for me. Also I am not a candicate for the latest IOL implants because of the lasik surgery. I am very upset at this point, and had I been informed of this prior to the surgery I would have never had the lasik surgery at all. I have also had very dry eyes ever since the surgery. I was told that I was a good candicate for the surgery and that the dry eye thing would not be a problem for me. This is extremely upsetting and patients should be informed in detail about this cataract situation. I think it would change a lot of minds to learn that the lasik thing can and usually does cause the cataracts and that this is difficult if not impossible to correcct without returning to glasses all over again. And I paid for lifetime enhancements and the Institue where the surgery was performed closed down and is gone. This is terrible to discover also. I have contacted them several times in the past few months, thinking that my vision problems were calling for enhancements ( the closest institute is in another state) and have been told evry time someone will get back with you, and they never have. I am thinking about seeing a lawyer concerning this part, because I was ripped off and they should have to refund my part paid for enhancements. I encourage anyone considering this surgery to think twice and more, it isn't worth it. I was better off wearing my contacts and glasses.
LASIK patient files report with FDA: Developed cataracts, denied records needed for cataract surgery - 4/23/2012
I had LASIK surgery for correction of shortsightedness. I did not realize if I was informed that I would need the preoperative measurements for subsequent cataract surgery. Now I am told this is a legal requirement from the Dr., but he says the files are too difficult to retrieve and it is being done safely without. The surgeon I now see says there are limitations without these measurements and I am afraid to proceed. Is it possible to legally demand my records? Is the LASIK company required to maintain these records also? I see nothing about this problem on any forums or where I can get better info. I feel people are not truly aware of such difficulties in this subsequent but necessary and common surgery. Can you help me in any way?
Psychologist Doreen Schleifer - 5/1/2012
I had LASIK 9 years ago-with great success. Went from -11 to 20/20 vision- until now. I developed aggressive cataracts (I am 50 years old). I had surgery with the LASIK surgeon thinking he knew my eyes. MISTAKE 1- he never looked at my old records and dismissed my concerns and complaints after surgery as those of an hysterical woman. I am now with another surgeon who says I was a poor candidate for LASIK which is causing all kinds of problems for IOLS,including double vision, poor vision at all distances, uncorrectable eye sight...
Patient email to LasikComplications.com 2/25/2010
Two days ago I went to my eye doctor, the same one who performed my lasik 9 years ago. Dr. informs me I have the cataracts in both eyes. I am 46 years of age. NO ONE in my family, under the age of 65, has ever been diagnosed with cataracts. I am wondering if these "early onset" cataracts could have been caused by the lasik. Granted, there are other factors, like being in the sun, at the beach, as a child etc, but none of my siblings have these issues, not even wearing glasses, and now for me to have cataracts in BOTH eyes? I feel my doctor did make known the possible side effects, at least as they were known 9 years ago, so I do not particularly fault him for my current situation; however, I have a gut feeling that the lasik is directly related to my now having cataracts at 46 years old. I did ask my eye doctor if one caused the other and, of course, the doctor who performed the lasik is not going to acknowledge any relationship between the two. Any information you can provide would be helpful. Elizabeth Hill
National Eye Institute lists LASIK as a cause of cataract - 2/8/2009
From Outer Space to the Eye Clinic: New Cataract Early Detection Technique
Excerpt: The DLS technique will now assist vision scientists in looking at long-term lens changes due to aging, smoking, diabetes, LASIK surgery, eye drops for treating glaucoma, and surgical removal of the vitreous gel within the eye, a procedure known to cause cataracts within six months to one year. It may also help in the early diagnosis of Alzheimer’s disease, in which an abnormal protein may be found in the lens. In addition, NASA researchers will continue to use the device to look at the impact of long-term space travel on the visual system.
Adverse Event Reported to the FDA 6/10/2008
"I had lasik on both eyes in 2001. The first result was not good and i had one enhancement of my left eye and twice on my right eye. The right eye was still not fully corrected. In 2006, a regular eye exam found cataract in both of my eyes. It was worse in my right eye. In 2008, i had a cataract surgery for my right eye. I will have another surgery on my left eye at a later date. One of the eye doctors i have seen thought my cataract might be related to the lasik. If lasik could cause such side effect, this surgery should be prohibited or at least the dr should certainly let patients know the risk."
Adverse Event Reported to the FDA 5/21/2008
"I had lasik surgery on both eyes in 2003. My eyes were burnt red for 4 months. I had pressure in the right eye. At first the vision was fine - now i have cataracts that my physician said was caused by the lasik surgery. I went to a different dr and had the cataract removed on my right eye and now i still have to wear glasses because they could not correct the vision with the lens put in for the cataract surgery. I wish i would have never had lasik because now my eyes are ruined, and i have to wear glasses again."
IOL calculations after refractive surgery need extra care, Ophthalmology Times 2/1/2006
From the article: There has been a question of whether laser refractive surgery is accelerating the development of cataract. This is controversial, but I see it more and more often in my practice," he said. Dr. O'Brien is professor of ophthalmology and director of the Refractive Surgery Service, Bascom Palmer Eye Institute, Miami... "These patients who develop cataract after refractive surgery want a perfect outcome. They are potentially frustrated and angry because their quality of vision has suffered as the result of the refractive surgery, and the results may be unpredictable. Interestingly, incorrect power is the most common reason for IOL explantation. This is the result of our not being able to determine the power as accurately as we would like," he stated and advised exercising extra care with these patients.
Posts from the old Surgical Eyes Bulletin Board
Post 1: "Hello. At this moment, I am three months post lasik. One month after the procedure, I developed cataracts in both eyes. They WERE NOT there before the surgery. I have read other cases where cataracts developed quickly after lasik surgery, though the medical profession will not account that lasik caused this. I am 23 years old. I am taking no medication. I do not have any other explanation to why my cataracts developed besides the lasik procedure. The likelyhood is just too great."
Post 2: "Immediately prior to my LASIK surgery in February 1999, my eyes were examined by an ophthalmologist and an optometrist in my pre-op appointments. Both pronounced my eyes to be very healthy, just very myopic. I was -13.5 right and -14.5 left. Nobody suggested that I might be at a higher risk for complications due to the severity of my nearsightedness. The surgery was uneventful. Immediately afterwards my eyes became very dry, and my vision began to get increasingly worse, like I had Vaseline in them. The opthalmologist was concerned and had me return for frequent follow-up visits. He had me continue taking 4 drops of FML, a topical steroid eyedrop, for 6 weeks to combat the dry eyes and in hopes of improving the vision. At each visit my best corrected vision declined until at 6 weeks I was about 20/100 in both eyes. It was at this visit that the doctor found small posterior subcapsular cataracts in both eyes--dead center where the laser would have worked. We were all shocked. Both doctors confirmed (one in writing) that the cataracts were not there before LASIK. I was 39 years old then, had no family history of cataracts or other risk factors for cataracts, and had never used steroids except for the 4 drops of FML for 6 weeks."
This was posted by an ophthalmologist in response: "On many different threads I have repeatedly brought attention to the alarming frequency of cataracts arising shortly after LASIK or PRK. The point that I have been unsuccessful in bringing across is that, if you suspected you would need cataract/implant surgery to begin with, you would never have LASIK or PRK because cataract/implant surgery can itself correct all refractive errors and even astigmatism to a large extent. To repeat, these cataracts have been reported again and again in relatively young customers who have taken no or innocuous doses of steroids."
Articles regarding damage to the crystalline lens and induced cataract after LASIK:
Case Report Ophthalmol. 2012 May;3(2):262-5.
Cataractogenesis after Repeat Laser in situ Keratomileusis.
Mansour AM, Ghabra M.
Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.
Abstract: There has been the unsubstantiated clinical impression that laser refractive surgery accelerates cataract development along with solid experimental data about the cataractogenic effects of excimer laser treatment. We present the first documented case of significant cataract formation in a young myope after repeat excimer laser ablation necessitating phacoemulsification with a posterior chamber implant. Proposed explanations include focusing of the ablation wave on the posterior capsule (acoustic wave lens epithelial damage), photooxidative stress of the lens (ultraviolet and inflammatory oxidative stress), and corticosteroid-induced cataract (lens toxicity).
Am J Ophthalmol. 1999 Oct;128(4):507-9.
Iatrogenic cataract after laser-assisted in situ keratomileusis.
Nakamura K, Bissen-Miyajima H, Arai H, Toda I, Hori Y, Shimmura S, Tsubota K.
Department of Ophthalmology, Tokyo Dental College, Chiba, Japan. QYJ15752@nifty.ne.jp
PURPOSE: To report a case of corneal opacity and iatrogenic cataract after laser-assisted in situ keratomileusis.
METHOD: Case report. A 44-year-old man was initially seen with a traumatic cataract, corneal stromal opacity, and defect of the endothelium in the right eye after laser-assisted in situ keratomileusis performed by a plastic surgeon who had no ophthalmologic training.
RESULTS: It was speculated that repeated ablations resulted in corneal perforation. We immediately performed phacoemulisification to remove the cataract and to prevent phacolytic glaucoma. However, visual acuity remained 20/200 because of the corneal stromal opacity, and penetrating keratoplasty was performed 2 months later, which improved best-corrected visual acuity to 20/30.
CONCLUSIONS: This case demonstrated that laser-assisted in situ keratomileusis can cause devastating damage to the eye.
Ophthalmology. 2001 Jun;108(6):1070-4.
Stress wave amplitudes during laser surgery of the cornea.
Krueger RR, Seiler T, Gruchman T, Mrochen M, Berlin MS.
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
PURPOSE: To determine the stress wave amplitudes generated during photoablation of the cornea using an argon fluoride excimer laser.
DESIGN: Experimental study using porcine eyes. METHODS: Profiles of the stress wave amplitudes and enucleated human eyes along the axis of symmetry of porcine eyes and enucleated human eyes were measured using a miniature piezoelectric transducer. The ablation parameters, fluence, and ablation diameters were varied within the range of clinical application.
MAIN OUTCOME MEASURES: Stress wave amplitudes generated during photoablation.
RESULTS: The stress waves pass through a pressure focus located in the posterior lens and anterior vitreous, where amplitudes of up to 100 atm were measured with a 6-mm or larger ablation zone. Posterior to this focus, the stress wave amplitudes rapidly decrease to less than 10 atm at the retinal site. Small diameter excimer laser spots (< or =1.5 mm) produce a declining stress wave with no pressure focus at the lens and anterior vitreous.
CONCLUSIONS: Stress waves may be potentially hazardous to anterior structures of the human eye, including the corneal endothelium, lens and anterior vitreous face. They peak at the lens and vitreous with a broad beam, but not with small spot laser ablation. At posterior retinal and subretinal structures, they may be considered harmless.
Cornea 2000 Jan;19(1):75-9
PRK and LASIK--their potential risk of cataractogenesis: lipid peroxidation changes in the aqueous humor and crystalline lens of rabbits.
Wachtlin J, Blasig IE, Schrunder S, Langenbeck K, Hoffmann F.
Department of Ophthalmology, Free University of Berlin, Germany.
PURPOSE: There are insufficient data on the possible cataractogenic side effects of excimer laser corneal surgery. Higher malondialdehyde (MDA) levels could indicate oxidative events related to the cataractogenic process. We therefore examined MDA levels after refractive laser surgery.
METHODS: Six white Russian rabbits received laser in situ keratomileusis (LASIK) (Schwind keratome) in the right eye and a 250-microm-deep microkeratome cut (Schwind microkeratome) in the left eye. Six others underwent photorefractive keratectomy (PRK) in the right eye; the left eye remained untreated. The 180 mJ/cm2 fluence applied at a rate of 10 Hz with an optical zone diameter of 5 mm in all rabbits (438 pulses) resulted in an estimated central photoablation depth of 116 microm. Two weeks later, lenses and aqueous were taken immediately after death. MDA was detected in aqueous and homogenate of lenses after reacting with thiobarbituric acid (TBA). MDA bound to TBA (MDA-TBA) was specifically analyzed by high-performance liquid chromatography (HPLC) (excitation, 525 nm; emission, 551 nm) using phosphate-buffered methanol as eluent.
RESULTS: No significant laser-induced MDA alteration was found in either the aqueous or the lens. The microkeratome group, however, had two to three times higher MDA levels in the lenses than the control group (p = 0.12) or the PRK (p = 0.03) group.
CONCLUSION: Elevation of MDA in the lens of the microkeratome group indicates that LASIK, but not PRK, may be a risk factor in cataractogenesis. The increased MDA levels in the LASIK group are probably caused by the microkeratome incision rather than the secondary radiation of the excimer laser. Postoperative inflammation may explain the surprising results.
Exp Eye Res 1994 Apr;58(4):453-7
ArF 193 nm excimer laser corneal surgery as a possible risk factor in cataractogenesis.
Costagliola C, Balestrieri P, Fioretti F, Frunzio S, Rinaldi M, Scibelli G, Sebastiani A, Rinaldi E.
Eye Clinic, 1st School of Medicine, Federico II University, Naples, Italy.
It was evaluated whether ArF 193 nm excimer laser corneal surgery represents a risk factor in cataractogenesis. For this purpose, 20 male albino rabbits underwent a photorefractive keratectomy and biochemical analyses on aqueous humour (hydrogen peroxide, ascorbic acid, and reduced and oxidized glutathione) and on lens (malondialdehyde, reduced and oxidized glutathione) were performed. In the aqueous humour of all treated animals a significant increase in hydrogen peroxide and in oxidized glutathione and a concomitant decrease in ascorbic acid and reduced glutathione concentration were observed. Moreover, all these variations were significantly correlated with the cumulative UV dose used. In the lens, after excimer laser corneal surgery, there was a dramatic loss of reduced glutathione and a parallel increase in oxidized glutathione levels. Malondialdehyde concentration was also increased, but only at the highest UV exposure. Moreover, all these variations were significantly correlated with the cumulative UV dose used. These findings demonstrate that the exposure of aqueous humour and lens to the secondary radiation generated after ArF 193 nm excimer laser corneal photoablative keratectomy induces biochemical modifications which are known to be markers of cataractogenesis.
From the full text: "So, before the large-scale introduction of such surgical procedure, further studies are required to verify whether the defense systems are able to prevent the occurrence of lens damage."
Lasers Surg Med 1994;14(2):168-77
Books ArF-excimer laser-induced secondary radiation in photoablation of biological tissue.
Lubatschowski H, Kermani O, Otten C, Haller A, Schmiedt KC, Ertmer W. Institut fur Angewandte Physik, Universitat Bonn, Germany.
Secondary radiation, emitted during and after the irradiation of corneal, dermal, and dental tissue by an ArF-excimer laser (193 nm), was qualitatively and quantitatively characterized. Emission of secondary radiation was found in the range of 200-800 nm. The intensity of secondary radiation in the range of 200-315 nm (UVC and UVB) is approximately 20% of the total intensity at high laser fluences (> 2 J/cm2), and approximately 50% at moderate laser fluences ( 5 J/cm2) are required. As a consequence, laser-induced plasma formation can be observed. Secondary radiation can be used as a visible guide for selective removal of carious altered tissue. The data we have found might be of assistance in estimating potential hazards for future mutagenic studies in the field.
Ophthalmologe 1992 Apr;89(2):134-8
[193 nm Excimer laser photoablation of the cornea. Spectrum and transmission behavior of secondary irradiation].
Lubatschowski H, Kermani O. Institut fur Angewandte Physik, Universitat Bonn.
In order to estimate the photomutagenic and phototoxic potential involved we analyzed the spectrum and intensity of secondary radiation induced with a 193 nm excimer laser in photoablation of corneal tissue. The spectrum of secondary radiation was analyzed by an optical multichannel analyzer. A pyroelectrical detector was used to evaluate the energy of the secondary radiation. We found the secondary radiation to be in the range of ultraviolet to infrared. The spectrum has a relatively high quantity (20%) of radiation between 240 and 280 nm. The intensity of the secondary radiation depends on the energy fluence of the primary laser pulse and can reach a quantum yield of up to 10(-3) (at 800 mJ/cm2). At a fluence of 230 mJ/cm2 (193 nm), the secondary radiation in the range of 240-280 nm is approximately 5 microJ/cm2. Radiation below 300 nm was not transmitted through the cornea. Since the high genetic activity of UV radiation in the range from 240-280 nm is well known, evaluation of the potential mutagenicity of 193 nm excimer laser radiation should take into consideration the presence of secondary radiation in this problematic spectral range. However, there is no incidence known for specific UV-induced corneal cancers, which supports the argument that the potential mutgenic risk of clinical excimer laser application can be considered to be low. Because of the full corneal absorption of radiation below 300 nm, there is no risk known for pigmented intraocular structures.
Fortschr Ophthalmol 1991;88(4):377-9
[Induction of chromosome aberrations in human lymphocytes as a model for evaluating the mutagenic effect of excimer laser irradiation in ophthalmology].
Forster W, Emmerich KH, Busse H, Scheid W, Weber J, Traut H. Universitats-Augenklinik, Munster, Bundesrepublik Deutschland.
A model for testing the mutagenicity of excimer laser radiation in ophthalmology is presented. In contrast to other studies using cell monolayers, in our study with this model human peripheral lymphocytes (heparinized whole blood) are exposed to laser irradiation at different conditions. The possible mutagenicity of secondary radiation after exposure of the cornea is also considered. The heparinized blood is either injected into the anterior chamber of an enucleated bovine eye or filled into a quartz chamber (positive control). After irradiation the lymphocytes are stimulated and fixed during metaphase, after which the metaphases are scored for chromatid and chromosome aberrations. In the positive control group, exposure to 248 nm excimer laser radiation (500 J, 277 mJ/cm2, 10 and 20 Hz) was followed by a highly significant increase in the yield of chromatid aberrations (chromatid breaks and achromatic lesions).
Graefes Arch Clin Exp Ophthalmol 1988;226(3):273-6
Side effects in excimer corneal surgery. DNA damage as a result of 193 nm excimer laser radiation.
Seiler T, Bende T, Winckler K, Wollensak J. Universitatsaugenklinik im Klinikum Charlottenburg, Berlin.
UV radiation is known to cause actinic damage to the DNA. Excimer laser light, possibly used for keratorefractive surgery, should not produce this damage, as the penetration depth is far less than the diameter of a cell. However, photoreactivation experiments with yeast cells show a significant amount of DNA repair after excimer irradiation. The zone of influence of a small slitlike exposure has a diameter of 2 cm. Consequently, the limbus, the critical location of epithelial neoplasia, always lies within the sphere of actinic damage. Radiation damage is induced by secondary radiation rather than by direct interaction.
Disclaimer: The information contained on this web site is presented for the purpose of warning people about LASIK complications prior to surgery. LASIK patients experiencing problems should seek the advice of a physician.